Ether hydrochloride → HCID 66762688, compound

HRID 578631Notes

Reaction equation

HRID 578631 reaction equation
[NH2:1][C:2]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][N:10]=[C:9]2[NH:14][CH2:15][C:16]1[CH:17]=[C:18]([NH:22]C(=O)OC(C)(C)C)[CH:19]=[CH:20][CH:21]=1)=[O:3].Cl.CCOCC>C(Cl)Cl>[NH2:22][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[CH2:15][NH:14][C:9]1[C:8]2[C:13](=[C:4]([C:2]([NH2:1])=[O:3])[CH:5]=[CH:6][CH:7]=2)[N:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 66763737HCID 66763737, compound

Product 1

HCID 66762688HCID 66762688, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared as light yellow solid in 97% yield by treating tert-butyl [3-({[8-(aminocarbonyl)quinazolin-4-yl]amino}methyl)phenyl]carbamate with 2N HCl/ether in DCM overnight. The precipitate was filtered, washed with ether and dried. Mass: M+H+: 294.

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-79c8d9dbac474358b143f118aa12ba9b
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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