4-{[(1R)-1-(3-nitrophenyl)ethyl]amino}quinazoline-8-carboxamide → 4-{[(1R)-1-(3-aminophenyl)ethyl]amino}quinazoline-8-carboxamide

HRID 578655Notes

Reaction equation

HRID 578655 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C@H:10]([NH:12][C:13]2[C:22]3[C:17](=[C:18]([C:23]([NH2:25])=[O:24])[CH:19]=[CH:20][CH:21]=3)[N:16]=[CH:15][N:14]=2)[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO>[NH2:1][C:4]1[CH:5]=[C:6]([C@H:10]([NH:12][C:13]2[C:22]3[C:17](=[C:18]([C:23]([NH2:25])=[O:24])[CH:19]=[CH:20][CH:21]=3)[N:16]=[CH:15][N:14]=2)[CH3:11])[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 667629844-{[(1R)-1-(3-nitrophenyl)ethyl]amino}quinazoline-8-carboxamide

Product 1

HCID 667628924-{[(1R)-1-(3-aminophenyl)ethyl]amino}quinazoline-8-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 4-{[(1R)-1-(3-nitrophenyl)ethyl]amino}quinazoline-8-carboxamide (1.50 g, 4.45 mmol) in methanol (125 mL) was shaken for 3 h in a

Sources & evidence

ORD record
ord-7810cde75d2a437d87ebae0c268bf45b
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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