Ethyl 2-chloro-1,3-oxazole-5-carboxylate → HCID 66763795, compound

HRID 578679Notes

Reaction equation

HRID 578679 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:10][C:11]2[C:20]3[C:15](=[C:16]([C:21]([NH2:23])=[O:22])[CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][N:12]=2)[CH3:9])[CH:5]=[CH:6][CH:7]=1.Cl[C:25]1[O:26][C:27]([C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:28][N:29]=1>>[CH2:33]([O:32][C:30]([C:27]1[O:26][C:25]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]([NH:10][C:11]3[C:20]4[C:15](=[C:16]([C:21](=[O:22])[NH2:23])[CH:17]=[CH:18][CH:19]=4)[N:14]=[CH:13][N:12]=3)[CH3:9])[CH:3]=2)=[N:29][CH:28]=1)=[O:31])[CH3:34]

Participants

3

Reactant 2

HCID 26369855Ethyl 2-chloro-1,3-oxazole-5-carboxylateHCID 66763381HCID 66763381, compound

Product 1

HCID 66763795HCID 66763795, compound

Procedure

2-{3-[1-(8-Carbamoyl-quinazolin-4-ylamino)-ethyl]-phenylamino}-oxazole-5-carboxylic acid ethyl ester was prepared according to Example 549 starting 4-{[1-(3-aminophenyl)ethyl]amino}quinazoline-8-carboxamide and ethyl 2-chloro-1,3-oxazole-5-carboxylate. LCMS (M+1) 447.

Sources & evidence

ORD record
ord-cafaf3eb4fd14ff393173ebe65d87581
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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