Triethylamine → HCID 86662381, compound

Participants

Reaction Conditions

Reaction Steps

2 g (6.75 mmol) [3-Hydroxy-1-(3-nitro-phenyl)-propyl]-carbamic acid tert-butyl ester were dissolved in 10 ml dichloromethane and 1.4 ml (20.1 mmol) triethylamine. Under ice-cooling, 1.54 g (8.10 mmol) toluene sulfonic acid chloride in 5 ml dichloromethane were added and the mixture was stirred 30 min at 0° C. and 18 h at room temperature. The reaction mixture was diluted with 10 ml water and 30 ml dichloromethane, the organic layer was separated and washed with water, dried over Na2SO4 and evaporated to dryness. The crude product was used without further purification. 3.05 g, Rt.=3.35 min (method C), LCMS: 351 (M-boc+H).

Provenance & Evidence