Methanol → HCID 66764016, compound

HRID 578686Notes

Reaction equation

HRID 578686 reaction equation
[NH2:1][CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].S(Cl)(Cl)=O.[CH3:21]O>>[CH3:21][O:6][C:5](=[O:7])[CH2:4][CH2:3][CH:2]([NH2:1])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 66763637HCID 66763637, compound

Product 1

HCID 66764016HCID 66764016, compound

Procedure

680 mg (2.49 mmol) 4-Amino-4-(3-nitro-phenyl)-butyric acid were suspended in 5 ml methanol and 635 μl (8.75 mmol) thionyl chloride were added. The mixture was stirred at room temperature overnight. The reaction mixture was evaporated to dryness, methanol was added and again evaporated to dryness.

Workup

  1. customThe reaction mixture was evaporated to dryness, methanol
  2. additionwas added
  3. customagain evaporated to dryness

Sources & evidence

ORD record
ord-57935829f1f74a9abdc61db098206a6f
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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