4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride → HCID 178513605, compound

HRID 578701Notes

Reaction equation

HRID 578701 reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[CH2:6][NH:7][C:8]1[C:17]2[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][N:9]=1.Cl[C:25]1[N:33]=[CH:32][N:31]=[C:30]2[C:26]=1[N:27]=[CH:28][NH:29]2>>[N:33]1[C:25]([NH:2][C:3]2[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=2)[CH2:6][NH:7][C:8]2[C:17]3[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=3)[N:11]=[CH:10][N:9]=2)=[C:26]2[C:30]([NH:29][CH:28]=[N:27]2)=[N:31][CH:32]=1

Participants

3

Reactant 2

HCID 667633584-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochlorideHCID 178478393HCID 178478393, compound

Product 1

HCID 178513605HCID 178513605, compound

Procedure

The title compound was prepared according to Example 549 starting 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and 6-Chloro-9H-purine. Reaction conditions: 120° C. in the microwave for 3 h:

Workup

  1. customReaction conditions

Sources & evidence

ORD record
ord-8980e91b7aac4abb904c176ebbb78640
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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