4-Methoxybenzoic Acid → 4-[5-(4-Methoxy-benzoylamino)-2-methyl-benzylamino]-quinazoline-8-carboxylic acid amide

HRID 578703Notes

Reaction equation

HRID 578703 reaction equation
COC1C=CC(C(N(C)C2C=C(C=CC=2)CN[C:15]2[C:24]3[C:19](=[C:20]([C:25]([NH2:27])=[O:26])[CH:21]=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)=O)=CC=1.[NH2:34][C:35]1[CH:36]=[CH:37][C:38]([CH3:43])=[C:39]([CH:42]=1)[C:40]#[N:41].[CH3:44][O:45][C:46]1[CH:54]=[CH:53][C:49]([C:50](O)=[O:51])=[CH:48][CH:47]=1>>[CH3:44][O:45][C:46]1[CH:54]=[CH:53][C:49]([C:50]([NH:34][C:35]2[CH:36]=[CH:37][C:38]([CH3:43])=[C:39]([CH:42]=2)[CH2:40][NH:41][C:15]2[C:24]3[C:19](=[C:20]([C:25]([NH2:27])=[O:26])[CH:21]=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)=[O:51])=[CH:48][CH:47]=1

Participants

4

Reactant 3

HCID 74784-Methoxybenzoic AcidHCID 27353655-Amino-2-methylbenzonitrileHCID 667640754-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid amide

Product 1

HCID 667624914-[5-(4-Methoxy-benzoylamino)-2-methyl-benzylamino]-quinazoline-8-carboxylic acid amide

Procedure

4-[5-(4-Methoxy-benzoylamino)-2-methyl-benzylamino]-quinazoline-8-carboxylic acid amide was prepared according to example 4-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid amide, starting from 5-Amino-2-methyl-benzonitrile and 4-methoxy-benzoic acid:

Sources & evidence

ORD record
ord-7a230a7d454b4c3880f54edcdb9bc177
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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