HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Cyano-phenyl)-4-methoxy-N-methyl-benzamide → N-(3-Aminomethyl-phenyl)-4-methoxy-N-methyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Cyano-phenyl)-4-methoxy-N-methyl-benzamide | HCID 47407961 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(3-Aminomethyl-phenyl)-4-methoxy-N-methyl-benzamide | HCID 62970261 | — |
Reaction Steps
450 mg (1.7 mmol) N-(3-Cyano-phenyl)-4-methoxy-N-methyl-benzamide were dissolved in 10 ml NH3 in methanol (10%) and 10 ml THF. 500 mg Sponge nickel catalyst were added and the mixture was hydrogenated for 14 h at 5 bar pressure. The mixture was filtered and the filtrate was evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040560B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-d08239081437489692c11e30e0e768c2 |
| Source note | uspto-grants-2015_05 |