Water → HCID 89569084, compound

Participants

Reaction Steps

In a reactor, a solution of mesyl chloride (280 g, 2.4 mol) in dichloromethane (2 L) was added to a mixture of [(1S,7R)-4-phenyl-3,5-dioxabicyclo[5.1.0]octan-1-yl]methanol (450 g, 2.0 mol) and triethylamine (310 g, 3.1 mol) in dichloromethane (4.7 L). A maximum internal temperature of 27° C. was observed. The mixture was stirred for 1 hour. Water (4.5 L) was added, phases were separated and the aqueous phase was extracted with dichloromethane (2.3 L). The combined organic phases were washed with water (2.3 L) and subsequently concentrated under reduced pressure yielding off-white solid product. This material was used as such in the next reaction step without further purification.

Provenance & Evidence