反应详情

温度

40 °C

[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)-3,5-difluorophenyl]boronic acid (19.3 g, 63.9 mmol; crude material, prepared by the method of Hattori, Bioorg. Med. Chem. 2006, 14, 3258-3262) was dissolved in 400 mL aqueous acetic acid (66%) and stirred at 40° C. for 5 h. The solution was then evaporated under reduced pressure, and the residue was purified by flash chromatography over silica gel (gradient elution from 0% to 2% methanol in dichloromethane) to give 3.46 g (25% of th., LC-MS purity 87%) of the title compound.

1. customcrude material, prepared by the method of Hattori, Bioorg
2. customThe solution was then evaporated under reduced pressure
3. customthe residue was purified by flash chromatography over silica gel (gradient elution from 0% to 2% methanol in dichloromethane)