tert-butyl 4-[6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate → Tert-butyl 4-[6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]piperidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 4-[6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (125 mg, 0.266 mmol) and palladium on activated carbon, reduced 10% (28 mg, 0.0266 mmol) in ethanol 10.0 mL was stirred under H2 balloon at 40° C. 18 h. The reaction was filtered through celite and wash with MeOH. The crude product was carried to next step.

Provenance & Evidence