反应详情

温度

95 °C

A solution containing 2-bromo-6-fluoropyridine (0.95 mL, 6.65 mmol and tert-butyl 6-methylpiperidin-3-ylcarbamate (750 mg, 3.32 mmol) in methyl sulfoxide 5.0 ml was heated 95° C. 18 h. The reaction was quenched with water then extracted with EtOAc. The organic layers was dried with sodium sulfate, filtered, and concentrated in vacuum. The crude product was purified by flash chromatography (EtOAc/Heptane eluted at 30% EtOAc) to give tert-butyl N-[1-(6-bromo-2-pyridyl)-6-methyl-3-piperidyl]carbamate (480 mg) in 39% yield. MS (ESI) m/z: 371.2

1. custom18 h
2. customThe reaction was quenched with water
3. extractionthen extracted with EtOAc
4. dry with materialThe organic layers was dried with sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuum
7. customThe crude product was purified by flash chromatography (EtOAc/Heptane eluted at 30% EtOAc)