Hydrochloric Acid → HCID 16657781, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-methoxycarbonyl-3-[2-chloro-5-(3,4-dihydroquinolin-1(2H)-ylsulfonyl)phenyl]thieno[3,4-d]-pyrimidine-2,4(1H,3H)-dione (0.2 g) in methanol (12 mL) -tetrahydrofuran (4 mL) was added lithium hydroxide-monohydrate (0.16 g), and the mixture was stirred at 60° C. overnight. To the reaction mixture was added 1 mol/L hydrochloric acid, and the precipitated crystals were collected by filtration. The crystals were washed with water and dried under reduced pressure to give the title compound (0.18 g).

Provenance & Evidence