Sodium Carbonate → 5-(Bromomethyl)-3-(3-(difluoromethoxy)phenyl)-2-ethoxypyrazine

HRID 578817Notes

Reaction equation

HRID 578817 reaction equation
[F:1][CH:2]([F:20])[O:3][C:4]1[CH:5]=[C:6]([C:10]2[C:11]([O:17][CH2:18][CH3:19])=[N:12][CH:13]=[C:14]([CH3:16])[N:15]=2)[CH:7]=[CH:8][CH:9]=1.[Br:21]C1C(OCC)=NC=C(C)N=1.B(O)O.C(=O)([O-])[O-].[Na+].[Na+]>CCO.C1(C)C=CC=CC=1.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[Br:21][CH2:16][C:14]1[N:15]=[C:10]([C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([O:3][CH:2]([F:1])[F:20])[CH:5]=2)[C:11]([O:17][CH2:18][CH3:19])=[N:12][CH:13]=1

Participants

8

Reactant 4

HCID 10340Sodium CarbonateHCID 61668Boronic AcidHCID 904146393-Bromo-2-ethoxy-5-methylpyrazineHCID 904155803-(3-(Difluoromethoxy)phenyl)-2-ethoxy-5-methylpyrazine

Product 1

HCID 904148165-(Bromomethyl)-3-(3-(difluoromethoxy)phenyl)-2-ethoxypyrazineYield 90%

Reagents, catalysts & solvents 3

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 702EthanolSolventHCID 1140TolueneSolvent

Procedure

3-(3-(Difluoromethoxy)phenyl)-2-ethoxy-5-methylpyrazine. A solution of 3-bromo-2-ethoxy-5-methylpyrazine (1.80 g, 8.29 mmol), 3-(difluoromethoxy)phenyl)boronic acid (2.03 g, 10.78 mmol), tetrakis(triphenylphosphine) palladium(0) (958.25 mg, 0.83 mmol), sodium carbonate (21.63 mL, 1.15 mol/L, 24.88 mmol), in EtOH (22 mL) and toluene (118 mL), under nitrogen, was heated at 88° C. for 1 h. The reaction mixture was extracted with EtOAc. The combined organic layers were dried (Na2SO4), and the solvent was removed under reduced pressure. Purification (FCC, SiO2, 0-50%, EtOAc/hexanes) afforded the title compound as a colorless oil (2.09 g, 90%). [M+H]=281.19.

Workup

  1. extractionThe reaction mixture was extracted with EtOAc
  2. dry with materialThe combined organic layers were dried (Na2SO4)
  3. customthe solvent was removed under reduced pressure
  4. customPurification (FCC, SiO2, 0-50%, EtOAc/hexanes)

Sources & evidence

ORD record
ord-0d9a870838244ce48fa6a7b22f458837
Source dataset
uspto-grants-2015_05
Patent number
US09040692B2

Reaction notes

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