1,2-dihydroisoquinoline → HCID 21816560, compound

HRID 578852Notes

Reaction equation

HRID 578852 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]1[C:11]([NH2:13])=[O:12].C1C2C(=CC=CC=2)C=CN1>>[CH:2]1([C:11]([NH2:13])=[O:12])[C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH:9]=[CH:10][NH:1]1

Participants

3

Reactant 2

HCID 4225111,2-dihydroisoquinolineHCID 53658481HCID 53658481, compound

Product 1

HCID 21816560HCID 21816560, compoundYield 50%

Procedure

Following the procedure for preparing amide from example 48, dihydroisoquinoline acid a (1.25 g, 6.2 mmol) prepared according to the procedures described by Deady et al. (J. Heterocyclic Chem. 2001, 38, 1185) afforded 754 mg (50%) of dihydroisoquinoline amide b as a yellow gum.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-af979360c0ad46cfbb8b777f10e5580d
Source dataset
uspto-grants-2015_05
Patent number
US09040706B2

Reaction notes

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