反应详情

温度

0 °C

2.90 g of Sodium hydroxide was dissolved in 10 ml of water and 1.94 g of benzyltriethylammonium chloride was added at ambient temperature. The solution was stirred and a solution of 2.00 g of (3-chloro-5-trifluoromethyl-pyridin-2-yl)-acetonitrile in 2.8 ml of 1-bromo-2-chloroethane was added dropwise. The reaction mixture was stirred at 60° C. for 3 h. The reaction mixture was then cooled to 0° C. and acidified to pH1 with concentrated aqueous hydrochloric acid (36%). The reaction mixture was extracted twice with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate, filtered and concentrated. Thus, 2.09 g of crude 1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropanecarbonitrile was obtained as a brown oil, which was used for the next step without further purification. 1H-NMR (CDCl3): 8.68 ppm (s, 1H), 8.00 ppm (s, 1H), 1.80 ppm (m, 2H), 1.70 ppm (m, 2H).

1. stirringThe reaction mixture was stirred at 60° C. for 3 h
2. extractionThe reaction mixture was extracted twice with ethyl acetate
3. washThe organic phase was washed with brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated