Potassium Carbonate → HCID 71558988, compound

Participants

Reaction Conditions

Reaction Steps

169 mg of 3-chloro-2-[1-(iodomethyl)cyclopropyl]-5-(trifluoromethyl)pyridine (step 3) and 110 mg of 2,6-difluoro-N-methoxy-benzamide were dissolved in dry dimethylsulfoxide under argon and 90 mg of potassium carbonate was added. The mixture was heated at 70° C. for 1 hour. Then ice water was added and the mixture was extracted with ether. The concentrated organic phase was purified on 30 g of silica gel, eluent hexane/ethyl acetate (4:1). Thus, 30 mg of N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide was obtained as a colorless resin. 1H-NMR (CDCl3): 8.70 ppm (s, 1H), 7.90 ppm (s, 1H), 7.32 ppm (m, 1H), 6.87 ppm (m, 2H), 4.24 ppm (s, 2H), 3.40 ppm (s, 3H), 1.19 ppm (m, 4H).

Provenance & Evidence