HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | N-t-butylthiocarbonyl-2,5-dichloro-4-nitroaniline | HCID 54175336 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole | HCID 19794200 | — |
Reaction Steps
A solution of 171 g of N-tert-butylthiocarbonyl-2,5-dichloro-4-nitroaniline (described in European patent application No. 85810418.5 published under No. 0175650) and 605 ml of N-methylpiperazine in 1700 ml of dimethylsulphoxide is heated at 140° for 8 hours, cooled and poured into water. The solid is filtered, washed with water and cold isopropanol to yield 2-tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole, melting at 132°-135°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246927 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-8d6c5e55a6af4dfdb2e2e90fcdc60967 |
| Source note | uspto-grants-1993_09 |