反应详情

Combined hydrazine (1.67 mL, 53.3 mmol) and a solution of N-benzyl-6-chloronicotinamide (2.19 g, 8.88 mmol) in ethanol (70 mL) and heated overnight at 100° C. The reaction mixture was then cooled and evaporated to give a solid. The solid was collected by filtration, washed with 70 mL water, and recrystallized from hot ethanol to give the title compound (1.32 g, 61%) as an off-white solid. MS m/z [M+H]+ 243.2.

1. temperatureThe reaction mixture was then cooled
2. customevaporated
3. customto give a solid
4. filtrationThe solid was collected by filtration
5. washwashed with 70 mL water
6. customrecrystallized from hot ethanol