Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl 3-(cyclobutyl(methyl)amino)azetidine-1-carboxylate | HCID 117601226 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | N-cyclobutyl-N-methylazetidin-3-amine | HCID 66186802 | — |
Reaction Steps
Combined a solution of tert-butyl 3-(cyclobutyl(methyl)amino)azetidine-1-carboxylate (285 mg, 1.186 mmol) in methylene chloride (6 mL) and added 4 M HCl in dioxane (1.186 mL, 4.74 mmol) and the solution stirred at 20° C. for 30 h. The solution was concentrated in vacuo and concentrated from heptane/methylene chloride to give the title compound as a hydrochloride acid salt (191 mg, 0.896 mmol, 76%) as a light yellow solid which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09040522B2 |
|---|
| Source dataset | uspto-grants-2015_05 |
|---|
| ORD ID | ord-8fce84382d6d45c8a09b53593ceffbe5 |
|---|
| Source note | uspto-grants-2015_05 |
|---|
