2-(Propan-2-yloxy)ethan-1-amine → HCID 178459182, compound

HRID 578967Notes

Reaction equation

HRID 578967 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[CH:5][CH:4]=1)#[N:2].[CH:24]([O:27][CH2:28][CH2:29][NH2:30])([CH3:26])[CH3:25]>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([NH:30][CH2:29][CH2:28][O:27][CH:24]([CH3:26])[CH3:25])=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[CH:7][CH:8]=1)#[N:2]

Participants

3

Reactant 2

HCID 5338662-(Propan-2-yloxy)ethan-1-amineHCID 178509615HCID 178509615, compound

Product 1

HCID 178459182HCID 178459182, compound

Procedure

The title compound was prepared in a manner similar to Example 74 using 6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 2-isopropoxyethanamine 1H NMR (400 MHz, DMSO-d6) δ 1.10 (d, J=6.06 Hz, 6 H) 3.42 (q, J=5.81 Hz, 2 H) 3.48-3.55 (m, 2 H) 3.55-3.64 (m, 1 H) 7.79 (d, J=8.34 Hz, 2 H) 8.15 (br. s., 2 H) 8.42 (d, J=7.58 Hz, 1H) 8.68 (br. s., 1 H) 8.77 (t, J=5.05 Hz, 1 H) 8.92 (s, 1 H) 13.54 (br. s., 1 H). MS m/z [M+H]+ 392.1.

Sources & evidence

ORD record
ord-42d6d2769311427eb5637199da2d1627
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

Loading…