Tetrahydrofurfurylamine → HCID 178426422, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (tetrahydrofuran-2-yl)methanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 1.49-1.67 (m, 1 H) 1.75-1.89 (m, 2 H) 1.89-2.01 (m, 1 H) 2.44 (s, 3 H) 3.35-3.42 (m, 2 H) 3.65 (q, J=7.49 Hz, 1 H) 3.80 (q, J=6.82 Hz, 1 H) 4.00 (t, J=6.32 Hz, 1 H) 7.67 (d, J=7.83 Hz, 1 H) 7.74 (s, 1 H) 7.78 (br. s., 1H) 8.18 (br. s., 1 H) 8.43 (d, J=6.57 Hz, 2 H) 8.82 (t, J=5.31 Hz, 1 H) 8.93 (s, 1 H) 13.20 (br. s., 1 H). MS m/z [M+H]+ 404.2

Provenance & Evidence