HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole → 6-Amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole | HCID 19794200 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole | HCID 19794176 | — |
Reaction Steps
A solution of 86 g of the above nitro compound in 150 ml of ethanol is hydrogenated in presence of 30 g of Raney nickel at 45°. The solution is filtered to give 6-amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole, melting at 130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246927 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-c4b9469cd7684e858e4abf2ec83970cc |
| Source note | uspto-grants-1993_09 |