反应详情

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)-1-cyclopropylethanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 0.18-0.26 (m, 1 H) 0.28-0.36 (m, 1 H) 0.36-0.44 (m, 1 H) 0.44-0.53 (m, 1 H) 0.92-1.08 (m, 1 H) 1.25 (d, J=6.82 Hz, 3 H) 2.43 (s, 3 H) 3.39-3.60 (m, 1 H) 7.66 (dd, J=8.08, 1.52 Hz, 1 H) 7.73 (s, 1 H) 7.78 (d, J=6.57 Hz, 1 H) 8.17 (br. s., 1 H) 8.43 (d, J=6.57 Hz, 2 H) 8.59 (d, J=8.08 Hz, 1 H) 8.79-9.05 (m, 1 H) 13.19 (br. s., 1 H). MS m/z [M+H]+ 388.2.