(Tetrahydro-2H-pyran-2-ylmethyl)amine → HCID 178426420, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (tetrahydro-2H-pyran-2-yl)methanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 1.17-1.31 (m, 2 H) 1.32-1.45 (m, 2 H) 1.77-1.91 (m, 4 H) 2.40-2.46 (m, 3 H) 3.37-3.49 (m, 1 H) 3.65-3.82 (m, 1 H) 4.58 (br. s., 1 H) 7.65 (dd, J=7.83, 1.52 Hz, 1 H) 7.73 (s, 1 H) 7.77 (d, J=7.83 Hz, 1 H) 8.16 (br. s., 1 H) 8.25-8.65 (m, 3 H) 8.80-9.01 (m, 1 H) 12.36-13.83 (m, 1 H). MS m/z [M+H]+ 418.2.

Provenance & Evidence