6-hydrazinyl-N-((tetrahydro-2H-pyran-4-yl)methyl)nicotinamide → HCID 178523065, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 188 using 6-hydrazinyl-N-((tetrahydro-2H-pyran-4-yl)methyl)nicotinamide and ethyl 3-(dimethylamino)-2-(2-oxopyridin-1(2H)-yl)acrylate. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.10-1.32 (m, 2H) 1.62 (d, J=12.9 Hz, 2 H) 1.81 (ddd, J=11.1, 7.3, 4.0 Hz, 1 H) 3.20 (t, J=6.3 Hz, 2 H) 3.24-3.31 (m, 2 H) 3.86 (dd, J=11.2, 2.7 Hz, 2 H) 6.31 (t, J=6.6 Hz, 1 H) 6.44-6.59 (m, 1 H) 7.48 (t, J=7.8 Hz, 1 H) 7.80 (br. s., 1 H) 8.27-8.61 (m, 2 H) 8.73 (br. s., 1 H) 8.92 (s, 1 H) 13.12 (br. s., 1 H). MS m/z 396 [M+H]+.

Provenance & Evidence