1,2-Dichloroethane → HCID 178433410, compound

Participants

Reaction Steps

Combined EDC (56.3 mg, 0.294 mmol), HOBT (39.7 mg, 0.294 mmol) and 6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid (45 mg, 0.147 mmol) in DMF (0.8 mL) then added 1-methylcyclopropanamine hydrochloride (47.4 mg, 0.441 mmol) and Hunig's base (0.180 mL, 1.028 mmol) and stirred at 20° C. for 16 h. The reaction mixture was diluted with 100 uL DMSO and purified by prep HPLC (ACN/water with formic acid) to give the title compound (27 mg, 51.1% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.60-0.68 (m, 2 H) 0.73-0.81 (m, 2 H) 1.40 (s, 3 H) 7.75 (d, J=8.6 Hz, 2H) 8.06-8.16 (m, 2 H) 8.35 (dd, J=8.6, 2.3 Hz, 1 H) 8.46 (d, J=8.8 Hz, 1 H) 8.54 (s, 1 H) 8.82-8.90 (m, 2 H) 13.53 (br. s., 1 H). MS m/z 360 [M+H]+.

Provenance & Evidence