1-(2-Methoxyethyl)cyclopropanamine hydrochloride → HCID 178494832, compound

HRID 579030Notes

Reaction equation

HRID 579030 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[CH:5][CH:4]=1)#[N:2].[CH3:24][O:25][CH2:26][CH2:27][C:28]1([NH2:31])[CH2:30][CH2:29]1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([NH:31][C:28]4([CH2:27][CH2:26][O:25][CH3:24])[CH2:30][CH2:29]4)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[CH:7][CH:8]=1)#[N:2]

Participants

3

Reactant 2

HCID 626773661-(2-Methoxyethyl)cyclopropanamine hydrochlorideHCID 178509615HCID 178509615, compound

Product 1

HCID 178494832HCID 178494832, compound

Procedure

The title compound was prepared in a manner similar to Example 198 using 6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-(2-methoxyethyl)cyclopropanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 0.58-0.73 (m, 4 H) 1.79 (t, J=6.9 Hz, 2 H) 3.14 (s, 3 H) 3.39 (t, J=6.9 Hz, 2 H) 7.72 (d, J=8.6 Hz, 2 H) 8.07 (d, J=7.8 Hz, 2 H) 8.27-8.34 (m, 1 H) 8.37 (br. s., 1 H) 8.57 (br. s., 1 H) 8.77 (s, 1 H) 8.79-8.83 (m, 1 H) 13.46 (br. s., 1 H). MS m/z 404 [M+H]+.

Sources & evidence

ORD record
ord-9421007bae0e4c32b0b8168967d17386
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

Loading…