1-(2-Methoxyethyl)cyclopropanamine hydrochloride → HCID 178494836, compound

HRID 579031Notes

Reaction equation

HRID 579031 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH3:23])[CH:17]=1.[CH3:24][O:25][CH2:26][CH2:27][C:28]1([NH2:31])[CH2:30][CH2:29]1>>[OH:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([NH:31][C:28]3([CH2:27][CH2:26][O:25][CH3:24])[CH2:30][CH2:29]3)=[O:12])=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH3:23])[CH:17]=1

Participants

3

Reactant 2

HCID 626773661-(2-Methoxyethyl)cyclopropanamine hydrochlorideHCID 178487655HCID 178487655, compound

Product 1

HCID 178494836HCID 178494836, compound

Procedure

The title compound was prepared in a manner similar to Example 198 using 6-(5-hydroxy-4-(2-methoxypyridin-4-yl)-1H-pyrazol-1-yl)nicotinic acid and 1-(2-methoxyethyl)cyclopropanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 0.57-0.73 (m, 4 H) 1.79 (t, J=7.1 Hz, 2 H) 3.14 (s, 3 H) 3.39 (t, J=7.1 Hz, 2 H) 3.79 (s, 3 H) 7.37 (br. s., 1 H) 7.44 (br. s., 1 H) 7.99 (d, J=5.6 Hz, 1 H) 8.31 (d, J=7.8 Hz, 2 H) 8.57 (br. s., 1 H) 8.77 (s, 1H) 8.79-8.84 (m, 1 H) 13.52 (br. s., 1 H). MS m/z 410 [M+H]+.

Sources & evidence

ORD record
ord-db9b27a7f0e04cd6925456a3f463c398
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

Loading…