1-(2-Methoxyethyl)cyclopropanamine hydrochloride → HCID 178494834, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 198 using 6-(4-(4-cyano-2-fluorophenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-(2-methoxyethyl)cyclopropanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 0.58-0.66 (m, 2 H) 0.66-0.73 (m, 2 H) 1.80 (t, J=6.9 Hz, 2 H) 3.14 (s, 3 H) 3.39 (t, J=7.1 Hz, 2 H) 7.61 (dd, J=8.2, 1.6 Hz, 1 H) 7.75 (dd, J=11.9, 1.5 Hz, 1 H) 8.14 (d, J=3.0 Hz, 1 H) 8.30 (dd, J=8.7, 2.1 Hz, 1 H) 8.40 (d, J=8.6 Hz, 1 H) 8.56 (t, J=8.0 Hz, 1 H) 8.76 (s, 1 H) 8.80 (d, J=1.5 Hz, 1H) 13.69 (br. s., 1 H). MS m/z 422 [M+H]+.

Provenance & Evidence