Trifluoroacetic acid → HCID 178422946, compound

Participants

Reaction Steps

The title compound, as a TFA salt, was prepared in a manner similar to Example 222 using 6-(4-bromo-5-methoxy-1H-pyrazol-1-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)nicotinamide and (2,6-dimethylpyridin-4-yl)boronic acid. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.15-1.27 (m, 2 H) 1.57-1.67 (m, 2 H) 1.77-1.86 (m, 1 H) 2.57 (br. s., 6H) 3.17-3.24 (m, 2 H) 3.24-3.32 (m, 2 H) 3.79-3.92 (m, 2 H) 8.06 (br. s., 2 H) 8.42-8.60 (m, 2 H) 8.72-8.86 (m, 2 H) 8.86-8.97 (m, 1 H) 14.03 (br. s., 1 H). MS m/z [M+H]+ 408.5.

Provenance & Evidence