HRID579060

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID44890807

2-(Trifluoromethoxy)ethan-1-amine--hydrogen chloride (1/1)

C3H7ClF3NO

结构：Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O

HCID178426451

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)NCCOC(F)(F)F)cn2)c1O

HCID178426446

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a manner similar to Example 227 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 2-(trifluoromethoxy)ethanamine hydrochloride. 1H NMR (400 MHz, DMSO-d6) δ 2.36 (s, 3 H) 3.55 (q, J=5.3 Hz, 2 H) 4.16 (t, J=5.3 Hz, 2 H) 7.59 (d, J=7.8 Hz, 1 H) 7.66 (s, 1 H) 7.71 (br. s., 1 H) 8.14 (br. s., 1 H) 8.36 (d, J=7.3 Hz, 1 H) 8.84-8.88 (m, 1 H) 8.93 (t, J=4.4 Hz, 1 H) 13.18 (br. s., 1 H). MS m/z [M+H]+ 432.4.