Formic Acid → HCID 178426424, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 284 using N,1-dimethylpiperidin-4-amine and 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid to give a formic acid salt (42 mg, 0.088 mmol, 70.6%) as a white solid. MS: 431 (M+H). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.71 (d, J=11.6 Hz, 2 H) 1.78-1.95 (m, 2 H) 2.35 (s, 3 H) 2.78 (s, 3 H) 2.92-3.83 (m, 7 H) 4.34 (br. s., 1 H) 7.43 (d, J=8.3 Hz, 1 H) 7.48 (s, 1 H) 7.76-7.88 (m, 2 H) 8.06-8.11 (m, 1 H) 8.38 (br. s., 1 H) 8.43 (d, J=8.8 Hz, 1 H).

Provenance & Evidence