4-Methoxypiperidine → HCID 178493262, compound

HRID 579090Notes

Reaction equation

HRID 579090 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[C:4]=1[F:25])#[N:2].[CH3:26][O:27][CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[F:25][C:4]1[C:5]([CH3:24])=[C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([N:31]4[CH2:32][CH2:33][CH:28]([O:27][CH3:26])[CH2:29][CH2:30]4)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])[CH:7]=[CH:8][C:3]=1[C:1]#[N:2]

Participants

3

Reactant 2

HCID 776664-MethoxypiperidineHCID 178422218HCID 178422218, compound

Product 1

HCID 178493262HCID 178493262, compound

Procedure

The title compound was prepared in a manner similar to Example 303 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 4-methoxypiperidine. 1H NMR (500 MHz, DMSO-d6) δ ppm 1.49 (br. s., 2 H) 1.75-1.97 (m, 2 H) 2.33 (d, J=1.95 Hz, 3 H) 3.11-3.68 (m, 7 H) 3.92 (br. s., 1 H) 7.64 (br. s., 1 H) 7.70-7.79 (m, 1 H) 8.07 (d, J=7.81 Hz, 1 H) 8.12-8.65 (m, 3 H). ESI-MS m/z [M+H]+ 436.3.

Sources & evidence

ORD record
ord-37cfeaf1f72b4d4d9cac550d45ee200d
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

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