6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine → 1-(3-methoxy-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepan-6-ol

Participants

Role	Name	HCID	Charge
Reactant	6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine	HCID 86707080	—
Reactant	Tert-butyl 4-(6-bromo-3-methoxy-2-pyridyl)-6-hydroxy-1,4-diazepane-1-carboxylate	HCID 86707101	—
Product	1-(3-methoxy-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepan-6-ol	HCID 86707102	4.5%

Reaction Steps

Following the procedures as described in EXAMPLE 86 and starting with 6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine and tert-butyl 4-(6-bromo-3-methoxy-2-pyridyl)-6-hydroxy-1,4-diazepane-1-carboxylate, 207 was obtained as an off-white solid (4.4 mg, 4.5%) over 2 steps. MS (ESI) m/z: 433.1 [M+H]+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09434725B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-691ffcbe880e44779e563a3610eed3f8
Source note	uspto-grants-2016_09