3-Methoxy-N-methylpropan-1-amine → HCID 178495289, compound

HRID 579100Notes

Reaction equation

HRID 579100 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[C:4]=1[F:25])#[N:2].[CH3:26][O:27][CH2:28][CH2:29][CH2:30][NH:31][CH3:32]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([N:31]([CH2:30][CH2:29][CH2:28][O:27][CH3:26])[CH3:32])=[O:21])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[C:4]=1[F:25])#[N:2]

Participants

3

Reactant 2

HCID 125459843-Methoxy-N-methylpropan-1-amineHCID 178422218HCID 178422218, compound

Product 1

HCID 178495289HCID 178495289, compound

Procedure

The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 3-methoxy-N-methylpropan-1-amine 1H NMR (400 MHz, DMSO-d6) δ ppm 1.66-1.93 (m, 2H) 2.34 (d, J=2.27 Hz, 3 H) 2.98 (s, 3 H) 3.07-3.67 (m, 7 H) 7.64 (br. s., 1 H) 7.70-7.81 (m, 1 H) 7.84-8.64 (m, 4 H). ESI-MS m/z [M+H]+ 424.3.

Sources & evidence

ORD record
ord-af8b796bcaf04495afd086aa7a12a2f3
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

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