1-(Azetidin-3-yl)piperidinato → HCID 178422208, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 303 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-(azetidin-3-yl)piperidine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.22-2.00 (m, 6 H) 2.33 (d, J=2.27 Hz, 3 H) 2.84 (br. s., 2 H) 3.23-3.70 (m, 2 H) 4.06-4.19 (m, 1 H) 4.33 (br. s., 2 H) 4.61 (br. s., 1 H) 4.66-4.77 (m, 1 H) 7.63 (d, J=7.07 Hz, 1 H) 7.75 (t, J=7.45 Hz, 1 H) 7.98-8.89 (m, 4 H). ESI-MS m/z [M+H]+ 461.3.

Provenance & Evidence