2-Methyl-2,6-diaza-spiro[3.3]heptane dihydrochloride → HCID 178422198, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 2-methyl-2,6-diazaspiro[3.3]heptane dihydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.33 (d, J=2.27 Hz, 3 H) 2.80 (d, J=4.55 Hz, 3 H) 3.94-4.67 (m, 8 H) 7.61 (d, J=8.08 Hz, 1 H) 7.69-7.78 (m, 1 H) 8.16-8.29 (m, 2 H) 8.42 (d, J=8.59 Hz, 1 H) 8.69 (br. s., 1 H). ESI-MS m/z [M+H]+ 433.3.

Provenance & Evidence