反应详情

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and N-methyl-1-(1-methylpiperidin-3-yl)methanamine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.09-1.27 (m, 1H) 1.45-1.92 (m, 3 H) 2.15 (br. s., 2 H) 2.37-2.47 (m, 4 H) 2.57-2.75 (m, 3 H) 2.96 (s, 4H) 3.28 (dd, J=12.88, 5.81 Hz, 3 H) 3.49 (d, J=15.41 Hz, 1 H) 7.47 (d, J=8.53 Hz, 1 H) 7.52 (s, 1 H) 7.84 (s, 1 H) 7.89 (br. s., 1 H) 8.20 (d, J=8.34 Hz, 1 H) 8.49 (br. s., 1 H) 8.52 (d, J=8.84 Hz, 1 H); ESI-MS m/z [M+H]+ 445.2.