HRID579123

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17999088

N-Methyl-1-[1-(propan-2-yl)pyrrolidin-3-yl]methanamine

C9H20N2

结构：Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O

HCID178426451

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)N(C)CC3CCN(C(C)C)C3)cn2)c1O

HCID178426432

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-(1-isopropylpyrrolidin-3-yl)-N-methylmethanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 1.21 (br. s., 5 H) 2.09 (br. s., 1 H) 2.42 (s, 3 H) 2.60-2.78 (m, 1 H) 2.90-3.09 (m, 4 H) 3.09-3.44 (m, 5 H) 7.44 (d, J=8.49 Hz, 1 H) 7.47 (s, 1 H) 7.76-7.80 (m, 1 H) 7.85 (d, J=7.33 Hz, 1 H) 8.30 (d, J=8.34 Hz, 1 H) 8.45 (br. s., 1 H) 8.55 (d, J=8.59 Hz, 1 H); ESI-MS m/z [M+H]+ 459.2.