(S)-1-Ethyl-2-methyl-piperazine → HCID 178462757, compound

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Reaction Steps

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)-1-ethyl-2-methylpiperazine. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.87-1.19 (m, 6 H) 2.42 (s, 3 H) 2.47 (br. s., 1 H) 2.52-2.59 (m, 1 H) 2.62-2.76 (m, 1 H) 2.77-2.98 (m, 2 H) 3.06 (d, J=10.61 Hz, 1 H) 3.35 (br. s., 1 H) 3.46-3.75 (m, 1 H) 4.05 (br. s., 1 H) 7.60 (dd, J=7.96, 1.64 Hz, 1 H) 7.66 (d, J=1.26 Hz, 1 H) 7.90 (d, J=8.34 Hz, 1 H) 8.01 (dd, J=8.72, 2.15 Hz, 1H) 8.06 (s, 1 H) 8.43 (d, J=8.59 Hz, 1 H) 8.51 (d, J=1.77 Hz, 1 H) 11.83-12.92 (m, 1 H); ESI-MS m/z [M+H]+ 431.3.

Provenance & Evidence