HCID 117600961, compound → HCID 178496734, compound

HRID 579126Notes

Reaction equation

HRID 579126 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[CH:4]=1)#[N:2].Cl.[CH3:26][O:27][C@H:28]([CH3:32])[CH2:29][CH2:30][NH2:31]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([NH:31][CH2:30][CH2:29][C@H:28]([O:27][CH3:26])[CH3:32])=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 117600961HCID 117600961, compoundHCID 178426451HCID 178426451, compound

Product 1

HCID 178496734HCID 178496734, compound

Procedure

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (R)-3-methoxybutan-1-amine hydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=6.32 Hz, 3 H) 1.58-1.79 (m, 2 H) 2.43 (s, 3 H) 3.24 (s, 3 H) 3.30-3.42 (m, 3 H) 7.66 (dd, J=7.83, 1.26 Hz, 1 H) 7.73 (s, 1 H) 7.77 (br. s., 1 H) 8.18 (br. s., 1 H) 8.29-8.59 (m, 2 H) 8.68 (t, J=5.31 Hz, 1 H) 8.87-8.94 (m, 1 H) 13.17 (br. s., 1 H); ESI-MS m/z [M+H]+ 406.2.

Sources & evidence

ORD record
ord-ad5d453cadab44a5b2d19348a3cf49ef
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

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