(2S)-1,2-dimethylpiperazine dihydrochloride → HCID 178426415, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)-1,2-dimethylpiperazine dihydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.16 (br. s., 3 H) 2.36 (s, 3 H) 2.60 (s, 3 H) 2.90 (br. s., 1 H) 3.04 (br. s., 1 H) 3.26 (br. s., 2 H) 3.41-3.57 (m, 1 H) 3.73 (d, J=17.68 Hz, 1 H) 4.29 (br. s., 1 H) 7.59 (dd, J=8.08, 1.52 Hz, 1 H) 7.66 (s, 1 H) 7.72 (d, J=8.08 Hz, 1 H) 8.03 (dd, J=8.59, 2.02 Hz, 1 H) 8.10 (s, 1 H) 8.35 (d, J=7.83 Hz, 1H) 8.51 (d, J=1.52 Hz, 1 H) 12.09 (br. s., 1 H); ESI-MS m/z [M+H]+ 417.3.

Provenance & Evidence