反应详情

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-cyclobutylpiperazine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.58-1.71 (m, 2 H) 1.76-1.90 (m, 2 H) 1.90-2.07 (m, 2 H) 2.37 (br. s., 4 H) 2.42 (s, 3 H) 2.83 (quin, J=7.71 Hz, 1 H) 3.44 (d, J=7.07 Hz, 2 H) 3.64 (br. s., 2 H) 7.63 (dd, J=7.96, 1.64 Hz, 1 H) 7.69 (s, 1 H) 7.84 (d, J=8.08 Hz, 1 H) 8.03 (dd, J=8.59, 2.27 Hz, 1 H) 8.11 (s, 1 H) 8.40 (d, J=8.59 Hz, 1 H) 8.52 (dd, J=2.27, 0.76 Hz, 1 H); ESI-MS m/z [M+H]+ 443.3.