HCID 117600929, compound → HCID 178456365, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)-2-methyl-1-propylpiperazine dihydrochloride. 1H NMR (500 MHz, DMSO-d6) δ ppm 0.86 (t, J=7.32 Hz, 3 H) 0.90-1.15 (m, 3 H) 1.35-1.56 (m, 2 H) 2.31-2.41 (m, 2 H) 2.43 (s, 3 H) 2.58-2.73 (m, 2 H) 2.81-3.01 (m, 1 H) 3.02-3.17 (m, 2 H) 3.44-3.65 (m, 1 H) 4.02 (br. s., 1 H) 7.62 (dd, J=8.05, 1.71 Hz, 1 H) 7.69 (d, J=0.98 Hz, 1 H) 7.86 (d, J=7.81 Hz, 1 H) 8.03 (dd, J=8.54, 2.20 Hz, 1 H) 8.08 (s, 1 H) 8.41 (d, J=8.30 Hz, 1 H) 8.52 (d, J=1.95 Hz, 1 H); ESI-MS m/z [M+H]+ 445.3.

Provenance & Evidence