HCID 29892937, compound → HCID 178426414, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (R)-1-isopropyl-2-methylpiperazine. 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 0.93 (br. s., 3 H) 1.01 (br. s., 2 H) 1.16 (br. s., 5 H) 2.43 (s, 1 H) 2.47 (s, 3 H) 2.61 (d, J=12.20 Hz, 1 H) 2.75-2.98 (m, 1 H) 3.07 (br. s., 1 H) 3.29 (br. s., 2 H) 4.39 (br. s., 1 H) 7.47-7.62 (m, 3 H) 7.68 (s, 1 H) 7.95-8.11 (m, 2 H) 8.44 (s, 1 H); ESI-MS m/z [M+H]+ 445.3.

Provenance & Evidence