HCID 117601231, compound → HCID 178426395, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)-3-(pyrrolidin-1-yl)piperidine dihydrochloride. 1H NMR (500 MHz, DMSO-d6) δ ppm 1.42-1.55 (m, 1 H) 1.61 (d, J=9.76 Hz, 1 H) 1.77 (br. s., 5 H) 2.06 (d, J=8.79 Hz, 1 H) 2.42 (s, 3 H) 2.77 (br. s., 2H) 2.87-3.09 (m, 2 H) 3.12-3.24 (m, 2 H) 3.33 (br. s., 1 H) 3.47-3.92 (m, 1 H) 3.93-4.48 (m, 1 H) 7.53 (dd, J=8.30, 1.95 Hz, 1 H) 7.58 (s, 1 H) 7.90-7.95 (m, 2 H) 8.08 (d, J=7.81 Hz, 1 H) 8.46-8.51 (m, 2 H); ESI-MS m/z [M+H]+ 457.3.

Provenance & Evidence