HCID 117600532, compound → HCID 178426396, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (R)—N-cyclopropyl-N-methylpiperidin-3-amine dihydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.13-0.61 (m, 4 H) 1.38-1.64 (m, 2 H) 1.64-2.09 (m, 3 H) 2.15-2.41 (m, 3 H) 2.43 (s, 3 H) 2.55-2.86 (m, 2 H) 3.04 (br. s., 1 H) 3.49-3.87 (m, 1 H) 4.33-4.77 (m, 1 H) 7.65 (dd, J=8.08, 1.52 Hz, 1 H) 7.72 (s, 1 H) 7.81 (d, J=8.08 Hz, 1 H) 8.05 (dd, J=8.59, 2.02 Hz, 1 H) 8.13 (s, 1H) 8.40 (d, J=7.33 Hz, 1 H) 8.53 (d, J=1.77 Hz, 1 H); ESI-MS m/z [M+H]+ 457.3.

Provenance & Evidence