反应详情

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-5-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and N,N-dimethylazetidin-3-amine dihydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.37 (s, 3 H) 2.77 (br. s., 6 H) 4.07-4.18 (m, 1 H) 4.26 (br. s., 2 H) 4.52 (br. s., 1 H) 4.63 (br. s., 1 H) 7.70 (d, J=6.82 Hz, 1 H) 7.79 (d, J=11.37 Hz, 1 H) 8.19-8.26 (m, 2 H) 8.43 (d, J=8.84 Hz, 1 H) 8.69 (d, J=2.27 Hz, 1 H); ESI-MS m/z [M+H]+ 421.3.