4-Methyl-4,7-diazaspiro[2.5]octane dihydrochloride → HCID 178426481, compound

HRID 579147Notes

Reaction equation

HRID 579147 reaction equation
[C:1]([C:3]1[C:8]([F:9])=[CH:7][C:6]([C:10]2[CH:11]=[N:12][N:13]([C:16]3[CH:24]=[CH:23][C:19]([C:20]([OH:22])=O)=[CH:18][N:17]=3)[C:14]=2[OH:15])=[C:5]([CH3:25])[CH:4]=1)#[N:2].Cl.Cl.[CH3:28][N:29]1[CH2:36][CH2:35][NH:34][CH2:33][C:30]21[CH2:32][CH2:31]2>>[F:9][C:8]1[CH:7]=[C:6]([C:10]2[CH:11]=[N:12][N:13]([C:16]3[CH:24]=[CH:23][C:19]([C:20]([N:34]4[CH2:33][C:30]5([CH2:32][CH2:31]5)[N:29]([CH3:28])[CH2:36][CH2:35]4)=[O:22])=[CH:18][N:17]=3)[C:14]=2[OH:15])[C:5]([CH3:25])=[CH:4][C:3]=1[C:1]#[N:2]

Participants

3

Reactant 2

HCID 669365134-Methyl-4,7-diazaspiro[2.5]octane dihydrochlorideHCID 178426484HCID 178426484, compound

Product 1

HCID 178426481HCID 178426481, compound

Procedure

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-5-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 4-methyl-4,7-diazaspiro[2.5]octane dihydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.26-0.83 (m, 4 H) 2.41 (d, J=3.79 Hz, 6 H) 2.89 (br. s., 2 H) 3.40-3.91 (m, 4 H) 7.73 (d, J=7.07 Hz, 1H) 7.98 (d, J=11.87 Hz, 2 H) 8.20 (s, 1 H) 8.35-8.63 (m, 2 H); ESI-MS m/z [M+H]+ 447.3.

Sources & evidence

ORD record
ord-42b7909c231d440ea1f39496043fd8e1
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

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